Science Vitamine D

Door de Europese Unie toegestane gezondheidsclaims voor vitamine D:

  • is belangrijk voor de calcium- en fosforopname voor het behoud van sterke botten en een sterk gebit
  • goed voor de spieren
  • draagt bij aan het proces van celvernieuwing
  • ondersteunt de afweer van het lichaam
  • draagt bij aan een normale groei en ontwikkeling van de botten van kinderen
  • ondersteunt het immuunsysteem van kinderen

Wetenschappelijke studies met betrekking tot vitamine D:

Abboud, M., Rybchyn, M.S., Rizk, R., Fraser, D. R., & Mason, R. S. (2017). Sunlight exposure is just one of the factors which influence vitamin D status. // Photochemical & Photobiological Sciences
Al Mheid, I., Patel, R., Murrow, J., Morris, A., Rahman, A., Fike, L., Kavtaradze, N., Uphoff, I., Hooper, C., Tangpricha, V., Alexander, R. W., Brigham, K., & Quyyumi, A. A. (2011). Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. // Journal of the American College of Cardiology
Ananthakrishnan, A. N., Khalili, H., Higuchi, L. M., Bao, Y., Korzenik, J. R., Giovannucci, E. L., […] Chan, A.T. (2012). Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn’s Disease. // Gastroenterology
Anderson, J. L., May, H. T., Horne, B. D., Bair, T. L., Hall, N. L., Carlquist, J. F., Lappé, D. L., Muhlestein, J. B., & Intermountain Heart Collaborative (IHC) Study Group. (2010). Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. // The American Journal of Cardiology
Armas, L. A. G., Hollis, B. W., & Heaney, R. P. (2004). Vitamin D 2 Is Much Less Effective than Vitamin D 3 in Humans. // The Journal of Clinical Endocrinology & Metabolism
Arunabh, S., Pollack, S., Yeh, J., & Aloia, J. F. (2003). Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women. // The Journal of Clinical Endocrinology & Metabolism
Balion, C., Griffith, L. E., Strifler, L., Henderson, M., Patterson, C., Heckman, G., … Raina, P. (2012). Vitamin D, cognition, and dementia: A systematic review and meta-analysis. // Neurology
Bettoun, D. J., Burris, T. P., Houck, K. A., Buck, D. W., Stayrook, K. R., Khalifa, B., … Nagpal, S. (2003). Retinoid X Receptor Is a Nonsilent Major Contributor to Vitamin D Receptor-Mediated Transcriptional Activation. // Molecular Endocrinology
Bikle, D. D. (2014). Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. // Chemistry & Biology
Bischoff-Ferrari, H., Borchers, M., Gudat, F., Dürmüller, U., Stähelin, H., & Dick, W. (2004). Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age. // Journal of Bone and Mineral Research
Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T., & Dawson-Hughes, B. (2006). Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. // The American Journal of Clinical Nutrition
Bruce, D., Whitcomb, J. P., August, A., McDowell, M. A., & Cantorna, M. T. (2009). Elevated non- specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice. // International Immunology
Cannell, J.J., Hollis, B.W. (2008). Use of vitamin D in clinical practice. Alternative Medicine Review
Cashman, K. D., Dowling, K. G., Škrabáková, Z., Gonzalez-Gross, M., Valtueña, J., De Henauw, S., Moreno, L., Damsgaard, C. T., Michaelsen, K. F., Mølgaard, C., Jorde, R., Grimnes, G., Moschonis, G., Mavrogianni, C., Manios, Y., Thamm, M., Mensink, G. B., Rabenberg, M., Busch, M. A., … Kiely, M. (2016). Vitamin D deficiency in Europe: Pandemic? // The American Journal of Clinical Nutrition
Chandra, P., Wolfenden, L. L., Ziegler, T. R., Tian, J., Luo, M., Stecenko, A. A., … Tangpricha, V. (2007). Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: A case series. // Photodermatology, Photoimmunology & Photomedicine
Christensen, N., Søndergaard, J., Fisker, N., & Christesen, H. T. (2017). Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy: A Systematic Review. // The Pediatric Infectious Disease Journal
Doorenbos, C. R. C., van den Born, J., Navis, G., & de Borst, M. H. (2009). Possible renoprotection by vitamin D in chronic renal disease: Beyond mineral metabolism. // Nature Reviews. Nephrology
Dawson-Hughes, B., Harris, S. S., Lichtenstein, A. H., Dolnikowski, G., Palermo, N. J., & Rasmussen, H. (2015). Dietary Fat Increases Vitamin D-3 Absorption. // Journal of the Academy of Nutrition and Dietetics
Engelsen, O. (2010). The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status. // Nutrients
Eyles, D. W., Trzaskowski, M., Vinkhuyzen, A. A. E., Mattheisen, M., Meier, S., Gooch, H., Anggono, V., Cui, X., Tan, M. C., Burne, T. H. J., Jang, S. E., Kvaskoff, D., Hougaard, D. M., Nørgaard- Pedersen, B., Cohen, A., Agerbo, E., Pedersen, C. B., Børglum, A. D., Mors, O., … McGrath, J. J. (2018). The association between neonatal vitamin D status and risk of schizophrenia. // Scientific Reports
Farmacotherapeutisch kompas (z.d.) Colecalciferol.
Ford, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M., & for the RECORD Trial Group. (2014). Cardiovascular disease and vitamin D supplementation: Trial analysis, systematic review, and meta-analysis. // The American Journal of Clinical Nutrition
Fluss, J., Kern, I., de Coulon, G., Gonzalez, E., & Chehade, H. (2014). Vitamin D deficiency: A forgotten treatable cause of motor delay and proximal myopathy. // Brain and Development
Fukumoto, S., Matsumoto, T., Tanaka, Y., Harada, S.-I., & Ogata, E. (1987). Renal Magnesium Wasting in a Patient with Short Bowel Syndrome with Magnesium Deficiency: Effect of 1 α – Hydroxyvitamin D 3 Treatment*. // The Journal of Clinical Endocrinology & Metabolism
Gallagher, J. C., Yalamanchili, V., & Smith, L. M. (2013). The effect of vitamin D supplementation on serum 25OHD in thin and obese women. // Journal of Steroid Biochemistry and Molecular Biology
Ganji, V., Tangpricha, V., & Zhang, X. (2020). Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults. // Nutrients
Gao, Q., Kou, T., Zhuang, B., Ren, Y., Dong, X., & Wang, Q. (2018). The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis. // Nutrients
Gezondheidsraad (2012). Evaluatie van de voedingsnormen voor vitamine D.
Gezondheidsraad (2018). Kernadvies Voedingsnormen voor vitamines en mineralen voor volwassenen.
Goldacre, M., Hall, N., & Yeates, D. G. R. (2014). Hospitalisation for children with rickets in England: A historical perspective. // The Lancet
Grant, W. B., Lahore, H., McDonnell, S. L., Baggerly, C. A., French, C. B., Aliano, J. L., & Bhattoa, H. P. (2020). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID- 19 Infections and Deaths. // Nutrients
Gröber, U., Spitz, J., Reichrath, J., Kisters, K., Holick, M.F. (2013). Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare. // Dermatoendocrinology
Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2014). Vitamin D as a neurosteroid affecting the developing and adult brain. // Annual Review of Nutrition
Guo, C., Sinnott, B., Niu, B., Lowry, M. B., Fantacone, M. L., & Gombart, A. F. (2014). Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. // Molecular Nutrition & Food Research
Hardwick, L. L., Jones, M. R., Brautbar, N., & Lee, D. B. N. (1991). Magnesium Absorption: Mechanisms and the Influence of Vitamin D, Calcium and Phosphate. // The Journal of Nutrition
He, C.-S., Fraser, W. D., Tang, J., Brown, K., Renwick, S., Rudland-Thomas, J., Teah, J., Tanqueray, E., & Gleeson, M. (2016). The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes. // Journal of Sports Sciences
Heaney, R. P. (2005). The Vitamin D requirement in health and disease. // The Journal of Steroid Biochemistry and Molecular Biology
Herr, C., Greulich, T., Koczulla, R. A., Meyer, S., Zakharkina, T., Branscheidt, M., … Bals, R. (2011). The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. // Respiratory Research
Holick, M. F. (2002). Sunlight and vitamin D: Both good for cardiovascular health. // Journal of General Internal Medicine
Holick, M. F. (2003). Vitamin D: A millenium perspective: Vitamin D. // Journal of Cellular Biochemistry
Holick, M. F. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. // American Journal of Clinical Nutrition
Holick, M. F. (2006). High Prevalence of Vitamin D Inadequacy and Implications for Health. // Mayo Clinic Proceedings
Holick, M.F. (2007). Vitamin D deficiency. // New England Journal of Medicine
Houghton, L. A., & Vieth, R. (2006). The case against ergocalciferol (vitamin D2) as a vitamin supplement. // American Journal of Clinical Nutrition
Hujoel, P. P. (2013). Vitamin D and dental caries in controlled clinical trials: Systematic review and meta-analysis. // Nutrition Reviews
Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M.-R., & Virtanen, S. M. (2001). Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. // The Lancet
Institute of Medicine (1997). Dietary Reference Intakes for Ca, P, Mg, Vit D and F. National Academy Press: Washington D.C.
Iqbal, S. F., & Freishtat, R. J. (2011). Mechanism of action of vitamin D in the asthmatic lung. // Journal of Investigative Medicine: The Official Publication of the American Federation for Clinical Research
Janssen, H. C., Samson, M. M., & Verhaar, H. J. (2002). Vitamin D deficiency, muscle function, and falls in elderly people. // The American Journal of Clinical Nutrition
Jones, G. (2008). Pharmacokinetics of vitamin D toxicity. // The American Journal of Clinical Nutrition
Jørgensen, S. P., Agnholt, J., Glerup, H., Lyhne, S., Villadsen, G. E., Hvas, C. L., Bartels, L. E., Kelsen, J., Christensen, L. A., & Dahlerup, J. F. (2010). Clinical trial: Vitamin D3 treatment in Crohn’s disease – a randomized double-blind placebo-controlled study. // Alimentary Pharmacology & Therapeutics
Khan, A., Dawoud, H., & Malinski, T. (2018). Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3— Clinical implications for cardiovascular diseases. // International Journal of Nanomedicine
Kim, G., & Bae, J.-H. (2016). Vitamin D and atopic dermatitis: A systematic review and meta-analysis. // Nutrition
Knekt, P., Kilkkinen, A., Rissanen, H., Marniemi, J., Sääksjärvi, K., & Heliövaara, M. (2010). Serum Vitamin D and the Risk of Parkinson Disease. // Archives of Neurology
Kotsi, E., Perrea, D.N. (2018). Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis. // Attention Deficit and Hyperactivity Disorders
Koutkia, P., Chen, T. C., & Holick, M. F. (2001). Vitamin D intoxication associated with an over-the- counter supplement. // New England Journal of Medicine
Kunutsor, S. K., Burgess, S., Munroe, P. B., & Khan, H. (2014). Vitamin D and high blood pressure: Causal association or epiphenomenon? // European Journal of Epidemiology
Krall, E. A., Wehler, C., Garcia, R. I., Harris, S. S., & Dawson-Hughes, B. (2001). Calcium and vitamin D supplements reduce tooth loss in the elderly. // American Journal of Medicine
Levis, S., Gomez, A., Jimenez, C., Veras, L., Ma, F., Lai, S., Hollis, B., & Roos, B. A. (2005). Vitamin D Deficiency and Seasonal Variation in an Adult South Florida Population. // Journal of Clinical Endocrinology & Metabolism
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002). 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. // Journal of Clinical Investigation
Linus Pauling Institute, Micronutrient Information Center, Oregon State University (2018)
Lin, L., Zhang, L., Li, C., Gai, Z., & Li, Y. (2019). Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension. // Current Protein & Peptide Science
Locantore, P., Del Gatto, V., Gelli, S., Paragliola, R. M., & Pontecorvi, A. (2020). The Interplay between Immune System and Microbiota in Osteoporosis. // Mediators of Inflammation
Luxwolda, M. F., Kuipers, R. S., Kema, I. P., van der Veer, E., Dijck-Brouwer, D. A. J., & Muskiet, F. A. J. (2013). Vitamin D status indicators in indigenous populations in East Africa. // European Journal of Nutrition
Malluche, H. H., Monier-Faugere, M.-C., & Koszewski, N. J. (2002). Use and indication of vitamin D and vitamin D analogues in patients with renal bone disease. Nephrology, Dialysis, Transplantation. // Official Publication of the European Dialysis and Transplant Association – European Renal Association
Malihi Z, Lawes CMM, Wu Z, Huang Y, Waayer D, Toop L, Khaw K, Camargo CA, Scragg R, (2018). Monthly high-dose vitamin D3 supplementation and self-reported adverse events in a 4-year randomized controlled trial. // Clinical Nutrition
Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., … Camargo, C. A. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. // BMJ
Marx, S. J. (z.d.). Hyperparathyroid and Hypoparathyroid Disorders. // New England Journal of Medicine
Maurya, V. K., & Aggarwal, M. (2017). Factors influencing the absorption of vitamin D in GIT: An overview. // Journal of Food Science and Technology
Mazahery, H., Conlon, C. A., Beck, K. L., Mugridge, O., Kruger, M. C., Stonehouse, W., … von Hurst, P. R. (2019). A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder. // The Journal of Steroid Biochemistry and Molecular Biology
Munger, K. L., Zhang, S. M., O’Reilly, E., Hernán, M. A., Olek, M. J., Willett, W. C., & Ascherio, A. (2004). Vitamin D intake and incidence of multiple sclerosis. // Neurology
Muris, A.H., Smolders, J., Rolf, L., Thewissen, M., Hupperts, R., Damoiseaux, J. (2016). Immune regulatory effects of high dose vitamin D3 supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFNβ; the SOLARIUM study. // Journal of Neuroimmunology
Muskiet, F. A. J., & van der Veer, E. (2007). Vitamine D: Waar liggen de grenzen van deficiëntie, adequate status en toxiciteit? // Nederlands Tijdschrift voor Klinisch Chemische Labgeneeskunde
Muskiet, F. A. J., & Schuitemaker, G. E. (2013). Een kritische beschouwing van de aanbevelingen en de rationale van het Gezondheidsraadrapport ‘Evaluatie van de voedingsnormen voor vitamine D’// Nederlands Tijdschrift voor Klinisch Chemische Labgeneeskunde
MVO (2019). Toevoeging van vitaminen en mineralen.
Natural Medicines. Vitamin D/Professional handout/Interactions.
Nowak, A., Boesch, L., Andres, E., Battegay, E., Hornemann, T., Schmid, C., Bischoff-Ferrari, H. A., Suter, P. M., & Krayenbuehl, P.-A. (2016). Effect of vitamin D3 on self-perceived fatigue. // Medicine
Papadimitropoulos, E., Wells, G., Shea, B., Gillespie, W., Weaver, B., Zytaruk, N., … Guyatt, G. (2002). VIII: Meta-Analysis of the Efficacy of Vitamin D Treatment in Preventing Osteoporosis in Postmenopausal Women. // Endocrine Reviews
Patrick, R. P., & Ames, B. N. (2015). Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. // FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Pittas, A. G., Dawson-Hughes, B., Sheehan, P., Ware, J. H., Knowler, W. C., Aroda, V. R., … Staten, M. (2019). Vitamin D Supplementation and Prevention of Type 2 Diabetes. // New England Journal of Medicine
Saraf, R., Morton, S. M. B., Camargo, C. A., & Grant, C. C. (2016). Global summary of maternal and newborn vitamin D status—A systematic review. // Maternal & Child Nutrition
Schafer, A.L. (2017). Vitamin D and intestinal calcium transport after bariatric surgery. // Journal of Steroid Biochemistry and Molecular Biology
Shaffer, J. A., Edmondson, D., Wasson, L. T., Falzon, L., Homma, K., Ezeokoli, N., … Davidson, K. W. (2014). Vitamin D Supplementation for Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. // Psychosomatic Medicine
Shea, M. K., Loeser, R. F., McAlindon, T. E., Houston, D. K., Kritchevsky, S. B., & Booth, S. L. (2018). Association of Vitamin K Status Combined With Vitamin D Status and Lower-Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts. // Arthritis Care & Research
Sotirchos, E. S., Bhargava, P., Eckstein, C., Van Haren, K., Baynes, M., Ntranos, A., … Calabresi, P. A. (2016). Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. // Neurology
Spedding, S. (2014). Vitamin D and Depression: A Systematic Review and Meta-Analysis Comparing Studies with and without Biological Flaws. // Nutrients
Stoutjesdijk, E., Schaafsma, A., Kema, I. P., van der Molen, J., Dijck-Brouwer, D. A. J., & Muskiet, F. A. J. (2019). Influence of daily 10-85 μg vitamin D supplements during pregnancy and lactation on maternal vitamin D status and mature milk antirachitic activity. // British Journal of Nutrition
Sutton, A. L. M., & MacDonald, P. N. (2003). Vitamin D: More Than a “Bone-a-Fide” Hormone. // Molecular Endocrinology
Tangpricha, V., Turner, A., Spina, C., Decastro, S., Chen, T. C., & Holick, M. F. (2004). Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. // The American Journal of Clinical Nutrition
The DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. (2010). Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. // BMJ
Tripkovic, L., Lambert, H., Hart, K., Smith, C. P., Bucca, G., Penson, S., … Lanham-New, S. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25- hydroxyvitamin D status: A systematic review and meta-analysis. // American Journal of Clinical Nutrition
Tsoukas, C. D., Provvedini, D. M., & Manolagas, S. C. (1984). 1,25-dihydroxyvitamin D3: A novel immunoregulatory hormone. // Science
Van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. // International Journal of Endocrinology
Van Ballegooijen, A. J., Cepelis, A., Visser, M., Brouwer, I. A., van Schoor, N. M., & Beulens, J. W. (2017). Joint Association of Low Vitamin D and Vitamin K Status With Blood Pressure and Hypertension. Hypertension
Vieth, R. (1999). Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. // American Journal of Clinical Nutrition
Volmer, D. A., Mendes, L. R. B. C., & Stokes, C. S. (2015). Analysis of vitamin D metabolic markers by mass spectrometry: Current techniques, limitations of the “gold standard” method, and anticipated future directions: MEASURING VITAMIN D METABOLIC MARKERS BY MASS SPECTROMETRY. // Mass Spectrometry Reviews
Voortman, T., van den Hooven, E. H., Heijboer, A. C., Hofman, A., Jaddoe, V. W., & Franco, O. H. (2015). Vitamin D Deficiency in School-Age Children Is Associated with Sociodemographic and Lifestyle Factors. // Journal of Nutrition
Wacker, M., & Holick, M. F. (2013). Sunlight and Vitamin D: A global perspective for health. // Dermato-Endocrinology
Wang, L., Manson, J. E., Song, Y., & Sesso, H. D. (2010). Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. // Annals of Internal Medicine
Wat, H., & Dytoc, M. (2014). Off-label uses of topical vitamin D in dermatology: A systematic review. // Journal of Cutaneous Medicine and Surgery
Webb, Ann R. (2006). Who, what, where and when—Influences on cutaneous vitamin D synthesis. // Progress in Biophysics and Molecular Biology
Wielders, J. P. M., van Dormaël, P. D., Eskes, P. F., & Duk, M. J. (2006). [Severe vitamin-D deficiency in more than half of the immigrant pregnant women of non-western origin and their newborns]. // Nederlands Tijdschrift Voor Geneeskunde
Willett, W. (2013). Nutritional Epidemiology (Derde druk). New York: Oxford University Press.
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000). Decreased bioavailability of vitamin D in obesity. // American Journal of Clinical Nutrition
Xue, L.-N., Xu, K.-Q., Zhang, W., Wang, Q., Wu, J., & Wang, X.-Y. (2013). Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease: A Meta-analysis. // Inflammatory Bowel Diseases
Zipitis, C. S., & Akobeng, A. K. (2008). Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis. //Archives of Disease in Childhood

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